Purification Technician
Job Description:
1.Responsible for the purification of antibody and antibody-drug conjugate;
2.Responsible for recording, sorting and analyzing the purification data on daily basis;
3.Complete routine work and record following lab rules;
4.Complete other duties assigned by upper manager.
Requirement:
1. Associate degree or above in biology or related majors;
2. Experience in antibody purification and production;
3. Deep hands-on experience on AKTA is required;
4.Experience (or eager to learn) in suspension cell culture and transient transfection expression of antibody.
Animal Researcher
Job Description:
1.Develop xenograft models, and in vivo screen anti-tumor agents;
2.Conduct animal immunization for the immunoscreening group;
3.Complete the notebook write-up in an up-to-date, accurate, complete, and scientific manner; reorganize and analyze the data collected in the experiment carefully, and write the report.
Requirement:
1.Bachelor or above degree in pharmacology, animal medicine or related fields; More than 5 years of experience in pharmaceutical or CRO companies;
2.Minimum 2-year working experience in preclinical pharmocology and pharmacodynamics; solid training in research and development; be familiar with mouse-related experiments; experience in molecular and cell biology experimental skills are preferred;
3.Strong Chinese and English literature reviewing capability; familiar with statistical analysis softwares; able to independently complete the experimental protocol design and pharmacological evaluation;
4.A thorough understanding of pharmacology knowledge and the basic principles of new drug R&D;
5.Able to make a work plan and complete relevant tasks independently according to the requirement of the company/project.
Antibody Engineering Scientist
Job Description:
1. Antibody engineering and function improvement;
2. Construction of monoclonal and bispecific antibody; cloning and evaluation of molecules;
3. Screening of monoclonal antibody drug;
4. Estabilshment of antibody humanization and affinify maturation platform.
Requirement:
1. Bachelor degree with 4+ years of relevant experience, or Master degree with 2+ years of relevant experience;
2. Major in molecular biology, biological technology, immunology, or related fields;
3. Have solid background and experience in molecular biology experiment, DNA/RNA knowledge and operation, and independent operation of molecular biology experiments; experience in phage display antibody library and hybridoma-based antibody generation; thorough understanding of antibody engineering, with experience in bispecific/bifunctional antibody;
4. Good teamwork and communation capability.
Job Description:
1. Hybridoma screening via ELISA technology;
2. Antibody-antigen binding identification via FACS technology;
3. Assay development for in-vitro potency of antibody;
4. Hybridoma cells culture and cell-line cryopreservation;
5. Screening, evaluation and identification of monoclonal antibodies for drug development;
6. Be good at troubleshooting and process optimization;
7. Be able to write the notebook and report in English clearly, accurately and detailedly; basic English communication is required.
Requirement:
1. Bachelor degree with at least 7+ years, or Master degree with 3+ years of experience, majoring in biochemistry, molecular biology, cell biology, immunology, or related fields;
2. Working experience in cell biology or immunology; good hands-on experience in mammalian cell culture, cell-based assay, and routine immunology technology such as ELISA, WB, etc;
3. Experience in hybridoma-based antibody generation and monoclonal antibody screening using ELISA and FACS;
4. Experience in in-vitro activity test of monoclonal antibody (antigen-antibody interaction, cell-based biology potency);
5. Good English literature reviewing and strong learning capabilities;
6. Good sense of responsibility and team-player; strong dedication and enterprising spirit; experience in team leading and project management is highly preferred.
Synthetic Chemist
Job Description:
1. Independently complete multi-step organic synthesis, and proficiently interpret spectrum of NMR, LCMS, and HPLC;
2. Quickly and accurately review literature, independently design synthetic routes, and solve problems encountered in the synthesis;
3. Complete experimental records and reports (in English) clearly, accurately and detailedly;
4. Cooperate with biology department, actively learn and fully master the synthesis, purification and characterization of antibody-drug conjugates.
Requirements:
1. Master degree (more than one year of working experience) in organic synthesis, pharmaceutical chemistry or related majors;
2. Have rich experience in organic synthesis, proficiency in organic synthesis unit operation and spectrum analysis, and strong hands-on experimental and trouble-shooting capability;
3. Able to review English literature proficiently, design rational synthesis routes, and conduct synthesis optimization;
4. Have a good/strong sense of responsibility, team spirit, and enterprise.
QA Specialist
Job Description:
1. Establish company's quality management system, review the relevant GLP and GMP documents, sign SOP documents, records and reports within the scope of work, and report any problem found in auditing to the QA director to make final decision;
2. Organize and implement quality control of R&D and pilot test process, including warehouse, QC, laboratory, production site, etc., and deal with on-site problems;
3. Prepare for audit and inspection, coordinate audit rectification, and track the implementation of rectification;
4. Formulate, modify and regularly review the quality standards, and check the implementation status and effectiveness of standards.
5. Organize and supervise the QC critical materials, retention samples of product, and stability studies;
6. Organize the investigation and auditing of deviation and change, and propose and track the implementation of CAPA.
7. Complete other tasks assigned by the superior.
Requirement:
1. Bachelor or above degree in pharmaceutical engineering, pharmacy, biomedicine or related majors; 3+ years of working experience in quality related positions; familiar with R&D process of biological drugs, preclinical study, cell culture, upstream/downstream process of protein expression, purification, and quality study and analysis; quality management experience is preferred;
2. Familiar with the laws, regulations and management systems of GLP, GMP and biological products, and management regulations for on-site inspection of preclinical sample production;
3. Good skills in audit, computer operation, and English reading/writing;
4. Strong sense of responsibility and team spirit; good communication skills and document writing ability.